hrp0086p1-p123 | Bone & Mineral Metabolism P1 | ESPE2016

Skeletal Manifestations in APECED

Laakso Saila , Toiviainen-Salo Sanna , Viljakainen Heli , Perheentupa Jaakko , Makitie Outi

Background: Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED or APS1) is an autosomal recessive disorder characterized by chronic candidiasis and autoimmune destruction of endocrine organs. Hypoparathyroidism (HP), adrenocortical failure (AF) and hypogonadism are the most common endocrinopathies, which together with their treatment may impact bone health. However, very little is known about the long-term skeletal health in patients with APECED.<p clas...